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M9490637.TXT
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1994-09-24
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Document 0637
DOCN M9490637
TI Prevalence of high serum and red cell ferritin levels in HIV-infected
patients.
DT 9411
AU Riera A; Gimferrer E; Cadafalch J; Remacha A; Martin S; Department of
Internal Medicine, Hospital de Sant Pau,; Universitat Autonoma de
Barcelona, Spain.
SO Haematologica. 1994 Mar-Apr;79(2):165-7. Unique Identifier : AIDSLINE
MED/94341737
AB We report a high prevalence of elevated serum and red cell ferritin (SF
and RCF) levels in 168 patients with HIV infection. SF levels increase
with clinical worsening of infection and with decreasing CD4+ lymphocyte
counts (ANOVA, p < 0.001) while RCF is significantly higher in
asymptomatic AIDS patients (ANOVA, p < 0.001) and in those treated with
zidovudine (AZT) (ANOVA, p < 0.001). It is suggested that, although
inflammatory processes may explain high SF levels, if we also take in
account RCF levels a possible association between iron overload and HIV
infection might exist, and this may be worsened by AZT treatment. The
significance of these high ferritin levels and their effects on immune
system suppression and susceptibility to infectious and neoplastic
complications in these patients merits further investigation.
DE Analysis of Variance Biological Markers/BLOOD Erythrocytes/*METABOLISM
Ferritin/*BLOOD Human HIV Infections/*BLOOD Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).